Ive been fighting with the above error for several days to try to get Sky Go working on a PC.
It transpires that there is an issue with newest version of Silverlight.
My answer was to remove Silverlight using the control pannel -> uninstall programs. Reboot and then download and install silverlight version 5.0.61118 The best place I found to download the earlier version was at http://www.oldapps.com/silverlight.php
This seemed to have fixed the issue for me.